AGEs increased migration and inflammatory responses of adventitial fibroblasts via RAGE, MAPK and NF-κB pathways
YY Liu, C Liang, X Liu, B Liao, X Pan, Y Ren, M Fan… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Advanced glycation end products (AGEs) and vascular adventitial fibroblasts
(AFs) are involved in diabetes-related vascular complications. However, the effect of AGEs
on AFs remains unclear. The aim of this study was to observe the impact of AGEs on cell
migration capacity and associated inflammatory responses of AFs. METHODS AND
RESULTS: Isolated vascular AFs of Sprague–Dawley rats were cultured, harvested after 24h
synchronization and challenged with AGE-HSA. AGE-HSA upregulated the expression of …
(AFs) are involved in diabetes-related vascular complications. However, the effect of AGEs
on AFs remains unclear. The aim of this study was to observe the impact of AGEs on cell
migration capacity and associated inflammatory responses of AFs. METHODS AND
RESULTS: Isolated vascular AFs of Sprague–Dawley rats were cultured, harvested after 24h
synchronization and challenged with AGE-HSA. AGE-HSA upregulated the expression of …
