High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure
Y Koyama, Y Takeishi, T Arimoto, T Niizeki… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: Pentosidine, one of the advanced glycation end products (AGE), is
generated by nonenzymatic glycation and oxidation of proteins. The receptor of AGE
(RAGE) is expressed in a variety of tissue, and interaction of AGE with RAGE induces
oxidative stress and activation of intracellular signaling, causing production of cytokines and
mediators of inflammation. We investigated whether serum pentosidine is a risk factor for
heart failure. METHODS AND RESULTS: Serum pentosidine concentration was measured …
generated by nonenzymatic glycation and oxidation of proteins. The receptor of AGE
(RAGE) is expressed in a variety of tissue, and interaction of AGE with RAGE induces
oxidative stress and activation of intracellular signaling, causing production of cytokines and
mediators of inflammation. We investigated whether serum pentosidine is a risk factor for
heart failure. METHODS AND RESULTS: Serum pentosidine concentration was measured …
